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DeCS
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Descriptor English:
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Encephalomyelitis, Autoimmune, Experimental
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Descriptor Spanish:
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Encefalomielitis Autoinmune Experimental
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Descriptor Portuguese:
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Encefalomielite Auto-Imune Experimental
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Synonyms English:
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Encephalomyelitis, Allergic
Autoimmune Encephalomyelitis, Experimental
Encephalomyelitis, Experimental Autoimmune
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Tree Number:
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C10.114.703.300
C10.314.350.250
C20.111.258.625.300
E05.598.500.500.500
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Definition English:
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An experimental animal model for central nervous system demyelinating disease. Inoculation with a white matter emulsion combined with FREUND'S ADJUVANT, myelin basic protein, or purified central myelin triggers a T cell-mediated immune response directed towards central myelin. The pathologic features are similar to MULTIPLE SCLEROSIS, including perivascular and periventricular foci of inflammation and demyelination. Subpial demyelination underlying meningeal infiltrations also occurs, which is also a feature of ENCEPHALOMYELITIS, ACUTE DISSEMINATED. Passive immunization with T-cells from an afflicted animal to a normal animal also induces this condition. (From Immunol Res 1998;17(1-2):217-27; Raine CS, Textbook of Neuropathology, 2nd ed, p604-5) |
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Indexing Annotation English:
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coordinate with specific demyelinating disease if pertinent; DF: ENCEPH ALLERGIC
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History Note English:
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2005 (1964)
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Allowable Qualifiers English:
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Record Number:
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4760
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Unique Identifier:
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D004681
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Occurrence in VHL:
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Similar:
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DeCS SciELO LILACS LIS
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